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Master internship + PhD: Design an flow properties of hydrogel-based granular materials

The main objectives are to formulate conductive hydrogel beads and to make a link with their flow and electrical properties.

Real-time adaptation of single cells to genetic changes and implications for bioprocesses

The way living cells adapt to mutations is complex, dynamic and heterogeneous. It is also a fundamental process of natural evolution which can be artificially applied to improve the yields of industrial bioprocesses. We propose to exploit two technological developments (one from biology and one from physical-chemistry) that, when combined together, have the potential to monitor the phenotype of individual de novo mutant cells, in real time and at very high throughput. This development can in principle have wide applications in biology. By using it on yeast cells, we expect to reveal fine-scale properties of a basic evolutionary force (the spectrum of phenotypic possibilities generated by mutations) and to describe metabolic burden (a natural limitation of bioproduction) at unprecedented resolution.