Publications

The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.

The invention concerns composite particles comprising a hydrophobic polymer and inorganic nanoparticles, said particles having a diameter of about 50 to 1000 nm, preferably about 100 to 500 nm, and advantageously from about 100 to 250 nm and comprising a hydrophobic polymer consisting of a polymer matrix and the inorganic nanoparticles stabilised and distributed relative homogeneously inside said matrix. The invention also concerns conjugates derived from said composite particles, their method of preparation and their uses.

The invention concerns a fractionable polydisperse stable double oil-in-water emulsion, consisting of 50 to 95 wt.%, relative to the total weight of the double emulsion, droplets of an invert monodisperse emulsion Ei dispersed in a continuous aqueous phase; the continuous aqueous phase comprising a polysaccharide thickening agent in a proportion of 1 to 10 wt.% relative to the total weight of the continuous aqueous phase; a water-soluble ethylene oxide and propylene oxide block copolymer as surfactant; and an osmotic pressure balancing agent; the emulsion Ei having a viscosity not higher than the viscosity of the continuous aqueous phase and consisting of 50 to 95 wt.%, relative to the total weight of Ei, droplets of an internal aqueous phase dispersed in an oily phase; the internal aqueous phase comprising at least an active hydrophilic substance; the oily phase comprising polyglycerol polyricinoleate as surfactant. The invention further concerns the corresponding monodisperse double emulsion of the same formulation and the method for preparing it starting from the claimed polydisperse double emulsion.

Water-redispersible granules including at least one active material in the form of a hydrophobic liquid, at least one non-ionic surfactant selected from polyoxyalkylene derivatives, and at least one water-soluble compound selected from polyelectrolytes belonging to the weak polyacid family, are disclosed. A method for preparing such granules by preparing an aqueous emulsion of at least one active material, at least one non-ionic surfactant and at least one water-soluble compound, and drying the resulting emulsion, is also disclosed.