Publications

A composition comprising in a continuous aqueous phase a monodisperse lipid phase comprising one or more crystallizable lipids, one or more active principles and a least one dispersed phase stabilizing compound comprising two fatty acid chains and a polyethylene glycol chain, is new. - Independent claims are included for a methods of preparing the claimed composition by: - (a) introducing the active principle(s) into the crystallizable lipid; - (b) dispersing the lipid phase in the aqueous phase in the presence of an emulsifier to form an emulsion; - (c) subjecting the emulsion to shear to form a monodisperse emulsion or where the lipid phase comprises an internal aqueous phase, by: - (i) dispersing an aqueous solution comprising the active principles into the lipid (which may contain one or more active principles) in a melted state in the presence of a lipophilic surfactant; - (ii) subjecting the emulsion obtained to shear to render it monodisperse; - (iii) incorporating the monodisperse emulsion in an aqueous phase in the presence of a stabilizer to form a double emulsion; and - (iv) subjecting the double emulsion to shear to produce a monodisperse double emulsion

Producing monodisperse biodegradable microspheres (I), comprising preparing an emulsion comprising at least one polymer phase containing an active agent (A) and at least one aqueous phase, the ratio of viscosities of the organic and aqueous phases being 0.1-10, subjecting the emulsion to controlled laminar shear, removing the solvent from the polymer phase, and recovering the obtained microspheres, is new.

Assembling colloidal particles in the form of irreversibly organized chains bearing species-recognition sites different from the ligands involved in organizing the particles, is new. Independent claims are also included for: (1) producing an assembly by assembling colloidal particles in the form of linear objects and contacting the objects with an agent capable of bridging them irreversibly; (2) producing an assembly by mixing and/or grafting colloidal particles with a bridging agent or bridging agent precursor, assembling the particles in the form of linear objects, and initiating bridging between the particles; (3) detecting, analysis, purification, identification, separation or ex-vivo monitoring of at least one species using an assembly; (4) a surface element bearing an assembly; (5) a hybridization array comprising the surface element of (4); (6) a microfluidic channel or cell comprising an assembly.